Endocrine Abstracts

Purpose: To identify predictive biomarkers of recurrence in NFPTs, we used heat shock protein profiling approach to correlate protein expression profiles with tumor recurrence. Heat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in tumors has been implicated in the regulation of apoptosis. In the current study, we attempted to clarify the significance of HSPs in NFPTs and their correlati...

Introduction: Hypopituitarism is the most frequent side effect of radiation or gamma knife radiosurgery (GKRS) for sellar diseases. There is a paucity of literature on the impact of GKRS on the hormonal profile of non-sellar diseases, even though the impact of radiation on pituitary hormones has been widely explored in sellar as well as non-sellar pathologies. In patients receiving treatment for non-sellar diseases, we assessed the effect of GKRS on hormonal p...

Background: No predictive biomarkers for NFPT recurrence have been identified, apart from Ki67. We employed high-throughput mass spectrometry-based analyses to examine the phosphorylation pattern of different subsets of NFPTs. Methods: Based on histopathological, radiological and surgical features, NFPTs were sub-grouped into three groups: non-invasive (n = 15), invasive (n = 10) and recurrent (n = 5) subtypes. Invasiveness was...

Background: No predictive biomarkers have been identified for clinically nonfunctioning pituitary tumour (NFPT) recurrence, with Ki67 being controversial. We employed quantitative mass spectrometry-based analyses to examine the differential expression of proteins in NFPTs.Methods: NFPTs were sub-grouped: non-invasive/non-recurrent group (NI/NR-G, n=5), invasive group (I-G, n=10) and recurrent group (R-G, n=5). Invasiveness was ...

Three hundred and thirty six cases of pituitary adenomas were operated by the transpenoidal route in the last 10 years by a single surgeon. Majority of these were giant non functioning adenomas. Prolactinomas were excluded unless a part of dual adenoma.In nearly 80% of tumours, total or near total removal was achieved. Long term outcome with follow up of more than 5 years revealed recurrence requiring resurgery in only 4 out of 102 patients. Endocrine re...

Background: There is no effective medical treatment available for non-functioning pituitary neuroendocrine tumours (NF-PitNETs). Recurrence (7-12%) or incomplete resection (30-45%) is a common feature. Thus, finding novel medical therapies to help the management of these tumours would be of great value. By using high-throughput mass spectrometry combined with functional characterisation, we explored novel therapeutic targets for NF-PitNETs.<p class="abstex...